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Article

Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis.

Angewandte Chemie (International ed. in English) - 2 May 2023

Fernández-Ramírez María Del Carmen, Ng Kevin Kan-Shing, Menéndez Margarita, Laurents Douglas V, Hervás Rubén, Carrión-Vázquez Mariano

Abstract excerpt

Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well-characterized pathological deposits but its aggregation mechanism is still poorly understood. Using single-molecule force spectroscopy based on a mechanical protection strategy, we studied the conformational landscape of the monomeric tau repeat domain (tau-RD244-368 ). We found two sets of...

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PMID: 36542681
DOI: 10.1002/anie.202209252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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