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Article

Common Features at the Start of the Neurodegeneration Cascade

29 May 2012

Abstract excerpt

Amyloidogenic neurodegenerative diseases are incurable conditions with high social impact that are typically caused by specific, largely disordered proteins. However, the underlying molecular mechanism remains elusive to established techniques. A favored hypothesis postulates that a critical conformational change in the monomer (an ideal therapeutic target) in these "neurotoxic proteins" triggers the pathogenic...

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PMID: 22666178
DOI: 10.1371/journal.pbio.1001335

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