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Article

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context.

Structure (London, England : 1993) - 5 Feb 2026

Bali Sofia, Wydorski Pawel M, Singh Ruhar, Van Nuland Nico E, Wosztyl Aleksandra, Morgan Nabil, Perez Valerie A, Chen Dailu, Chen Jie, Rizo Josep, Joachimiak Lukasz A

Abstract excerpt

The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. However, the structural relationship between aggregation propensity and biological activity remains unclear. We employed a multi-disciplinary approach,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41352343
DOI: 10.1016/j.str.2025.11.009
PMCID: PMC12695020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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