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Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage

1 Aug 2021

Abstract excerpt

We lack a holistic understanding of the genetic programs orchestrating embryonic colon morphogenesis and governing damage response in the adult. A window into these programs is the transcriptomes of the epithelial and mesenchymal cell populations in the colon. Performing unbiased single-cell transcriptomic analyses of the developing mouse colon at different embryonic stages (embryonic day 14.5 [E14.5], E15.5, and...

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PMID: 34348153
DOI: 10.1016/j.celrep.2021.109484

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