Article

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

2025-12-12

Abstract excerpt

While advances in single-cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single-cell RNA-seq, spatial transcriptomics by Slide-seq, and in situ multiplex RNA analysis to create a detailed spatial map of healthy and dysplastic colon cellular ecosystems and th...

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Literature Corpus work: 6caba5ac-b5b0-5120-b527-b59e2cc3adef
DOI: 10.7554/elife.104815.3

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