Article
Why Mutant Allele Frequencies in Oncogenes Peak Around 0.40 and Rapidly Decrease?
2016-04-07
Abstract excerpt
The mutant allele frequencies in oncogenes peak around 0.40 and rapidly decrease. In this article, we explain why this is the case. Invoking a key result from mathematical analysis in our model, namely, the inverse function theorem, we estimate the selection pressures of the mutations as a function of germline allele frequencies. Under complete dominance of oncogenic mutations, this selection function is expected...
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Identifiers and source
- Literature Corpus work
- 89fe4e25-58ba-51ec-aeee-86eff7097d1f
- DOI
- 10.1101/047563