Article
The guardians of inherited oncogenic vulnerabilities.
Evolution; international journal of organic evolution - 1 Jan 2016
Arnal Audrey, Tissot Tazzio, Ujvari Beata, Nunney Leonard, Solary Eric, Laplane Lucie, Bonhomme François, Vittecoq Marion, Tasiemski Aurélie, Renaud François, Pujol Pascal, Roche Benjamin, Thomas Frédéric
Abstract excerpt
Similar to seemingly maladaptive genes in general, the persistence of inherited cancer-causing mutant alleles in populations remains a challenging question for evolutionary biologists. In addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. We propose that although natural defenses evolve to...
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