Article

Somatic evolution of cancer genes on the sex chromosomes

2024-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Cancer progression arises through the somatic evolution of oncogenes (OGs) and tumour-suppressor genes (TSGs). According to Knudson’s two-hit hypothesis, both alleles of a TSG must typically be inactivated for tumorigenesis to proceed, whereas a single activating mutation can drive an OG. However, this diploid framework overlooks the distinct evolutionary dynamics of sex chromosomes. In males, t...

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Literature Corpus work: 3518b54e-131f-51c8-a675-08c07e0b1f30
DOI: 10.1101/2024.09.11.612525

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