Article

Oncogenic context shapes the fitness landscape of tumor suppression

2022-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the features of this landscape remain poorly understood and cannot be revealed by human cancer genotyping alone. Here, we use a multiplexed, autochthonous mouse platform to model and quantify the initiation and growth of more than one hundred genotypes o...

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Literature Corpus work: 24702a42-3671-5b6a-86e7-9b994c48becb
DOI: 10.1101/2022.10.24.511787

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