Article
Oncogenic context shapes the fitness landscape of tumor suppression.
Nature communications - 12 Oct 2023
Blair Lily M, Juan Joseph M, Sebastian Lafia, Tran Vy B, Nie Wensheng, Wall Gregory D, Gerceker Mehmet, Lai Ian K, Apilado Edwin A, Grenot Gabriel, Amar David, Foggetti Giorgia, Do Carmo Mariana, Ugur Zeynep, Deng Debbie, Chenchik Alex, Paz Zafra Maria, Dow Lukas E, Politi Katerina, MacQuitty Jonathan J, Petrov Dmitri A, Winslow Monte M, Rosen Michael J, Winters Ian P
Abstract excerpt
Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain poorly resolved and cannot be revealed by human cancer genomics alone. Here, we use a multiplexed, autochthonous mouse platform to model and quantify the initiation and growth...
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