Article

Genome-wide CRISPRi screen identifies basigin loss as protective in cardiac hypoxia

2026-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac function depends on continuous oxidative metabolism, rendering cardiomyocytes highly vulnerable to oxygen deprivation. Here, we performed a genome-wide CRISPR interference (CRISPRi) screen in human iPSC-derived cardiomyocytes to identify genes that modulate survival during chronic hypoxia. This screen revealed that knockdown of basigin (BSG), a chaperone for the monocarboxylate transport...

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Literature Corpus work: 89efb1df-c73b-5774-98d1-8a3d49761ff3
DOI: 10.64898/2026.01.26.701810

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