Article

GATA4 regulates mitochondrial biogenesis and functions during cardiac development and rescues cardiac and mitochondrial functions impaired by TKIs

2022-12-09

Abstract excerpt

<title>Abstract</title><p>Tyrosine kinase inhibitors (TKIs) have been widely used for cancer chemotherapy, but they also cause cardiotoxicities in cancer patients. In this study, we used human stem cells as an<italic>in-vitro</italic>system to interrogate the mechanisms underlying drug-induced toxicity in differentiated cardiomyocytes, including anticancer tyrosine kinase inhibitor (TKI) drugs, including imatinib,...

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Literature Corpus work: 5aaaa57a-23b1-5aa1-9c93-cc934a51bdf8
DOI: 10.21203/rs.3.rs-2343653/v1

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