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Genetic regulators of neuronal survival across metabolic environments

2025-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Cellular energy metabolism and oxygen availability shape neuronal function and vulnerability, yet the genetic regulators of these metabolic processes in human neurons remain incompletely understood. Here, we performed CRISPR interference (CRISPRi) screens in human induced pluripotent stem cell (iPSC)-derived neurons across four distinct metabolic conditions and at three physiologically relevant...

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Literature Corpus work
f6ee0299-4cc2-5654-9045-3c3452bbb1b8
DOI
10.64898/2025.12.19.695350
Open publication

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Genetic regulators of neuronal survival across metabolic environmentsDOI 10.64898/2025.12.19.695350
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