Article

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress

2026-06-02

Abstract excerpt

<h4>Background</h4> Impaired myocardial metabolism is a defining feature of heart failure, but many defective pathways and mechanisms remain to be identified. Prior studies find phosphoglycerate kinase and its synthesized product 3-phospho-glycerate required for the serine synthetic pathway (SSP) are reduced in human HFpEF myocardium. As serine is also provided exogenously, the impact of SSP reduction is uncertai...

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Literature Corpus work: 9ae90a93-67ef-5d22-bbbf-b32dc7f86e97
DOI: 10.64898/2026.05.29.728910

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