Article

TIGAR DEFICIENCY ENHANCES CARDIAC RESILIENCE THROUGH EPIGENETIC PROGRAMMING OF PARKIN EXPRESSION

2025-07-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> While mitochondrial dysfunction clearly drives cardiac deterioration in major heart diseases, the mechanisms controlling mitochondrial quality remain incompletely understood. This study investigated whether TIGAR (TP53-induced glycolysis and apoptosis regulator) deficiency influences cardiac protection through mitochondrial quality control pathways. <h4>METHODS</h4> We gene...

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Literature Corpus work: 8414b331-a2ee-541d-9494-50552ac60618
DOI: 10.1101/2025.07.14.664830

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