Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.

doi:10.1093/eurheartj/ehac305

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Article

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.

European heart journal - 21 Sept 2022

Perea-Gil Isaac, Seeger Timon, Bruyneel Arne A N, Termglinchan Vittavat, Monte Emma, Lim Esther W, Vadgama Nirmal, Furihata Takaaki, Gavidia Alexandra A, Arthur Ataam Jennifer, Bharucha Nike, Martinez-Amador Noel, Ameen Mohamed, Nair Pooja, Serrano Ricardo, Kaur Balpreet, Feyen Dries A M, Diecke Sebastian, Snyder Michael P, Metallo Christian M, Mercola Mark, Karakikes Ioannis

Abstract excerpt

AIMS: Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translating to a lack of disease-specific therapies. The discovery of novel targets for the treatment of DCM was sought using phenotypic sceening assays in induced...

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PMID: 35728000
DOI: 10.1093/eurheartj/ehac305
PMCID: PMC9794189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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