Article

Meclizine rescues cardiac function and mitochondrial ultrastructure by ATP- and glycolysis-independent mechanisms in a genetic model of mitochondrial energy dysfunction

2025-09-07

Abstract excerpt

<h4>ABSTRACT</h4> Primary mitochondrial cardiomyopathies are an unmet clinical challenge, as there are no therapies that directly address the underlying mitochondrial dysfunction. We previously reported that the cardiomyocyte-specific deletion of the mitochondrial phosphate carrier (SLC25A3), which imports phosphate required for ATP synthesis, produces a model of mitochondrial cardiomyopathy in which total cardia...

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Literature Corpus work: eae9cfea-c9dd-599d-b076-7101c94c74db
DOI: 10.1101/2025.09.03.674000

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