Article

Protective mitophagy in human hypoxic cardiomyocytes: mechanistic insights into SGLT2 inhibitor Dapagliflozin cardioprotection in ischemic injury

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>Background Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide, with cardiomyocyte death under hypoxic stress being a critical pathogenic mechanism. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) demonstrate cardiovascular benefits beyond glycemic control, yet their protective mechanisms in ischemic injury remain incompletely understood. Methods This s...

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Literature Corpus work: 57e46b18-ec96-5f7e-86eb-7ff299f75103
DOI: 10.21203/rs.3.rs-9239009/v1

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