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Article

Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature

1 Aug 2022

Abstract excerpt

Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine demethylases KDM6A and KDM6B, both of which have been implicated in a wide myriad of diseases, including blood and solid tumours, autoimmune and inflammatory disorders, and infectious diseases. Here, we review and summarise the pre-clinical evidence,...

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PMID: 35915507
DOI: 10.1186/s13148-022-01305-8

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