Article

Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responses

2023-07-25

Abstract excerpt

<title>Abstract</title> <p>NLRP3 inflammasome, as the archetypical molecular driver of inflammatory response, plays crucial roles in host defense and the maintenance of cell homeostasis. The demethylation of trimethylation of lysine 9 at histone 3 (H3K9me3, the repressive mark for euchromatic genes) is a prerequisite for the transcription of most genes. However, whether H3K9 demethylation is required for the indu...

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Literature Corpus work: 1aea3da6-1e03-59cb-abc0-d4f6660eee53
DOI: 10.21203/rs.3.rs-3138058/v1

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