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Article

Fibrosis—the tale of H3K27 histone methyltransferases and demethylases

5 Jul 2023

Abstract excerpt

Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic extracellular matrix (ECM). Currently, there is a lack of effective treatment options for fibrosis, highlighting an unmet need to identify new therapeutic targets. The acquisition of a fibrotic phenotype is associated with changes in chromatin...

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PMID: 37476157
DOI: 10.3389/fcell.2023.1193344

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