Article

Lysine methyltransferase SET7 links cardiometabolic risk to endothelial dysfunction by dysregulating mRNA splicing and eNOS-CaM interaction

2026-08-04

Abstract excerpt

<h4>BACKGROUND</h4> Lysine methyltransferase SET7 activates gene expression through mono- methylation of histone H3 at lysine 4 (H3K4me1) and modulates protein function via mono- methylation of non-histone proteins (Kme1). However, its role and molecular targets in endothelial dysfunction associated with cardiometabolic disorders remain unknown. <h4>METHODS</h4> Endothelial-specific Setd7 knockout ( Setd7 EC-K...

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Literature Corpus work: 983f107e-f2cb-538a-b9ea-f6cb139d47af
DOI: 10.64898/2026.08.02.742358

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