Article

A comprehensive analysis of RNA sequences reveals macroscopic somatic clonal expansion across normal tissues

2018-09-13

Abstract excerpt

Cancer genome studies have significantly advanced our knowledge of somatic mutations. However, how these mutations accumulate in normal cells and whether they promote pre-cancerous lesions remains poorly understood. Here we perform a comprehensive analysis of normal tissues by utilizing RNA sequencing data from ∼6,700 samples across 29 normal tissues collected as part of the Genotype-Tissue Expression (GTEx) proje...

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Literature Corpus work: 89861001-5f9f-50e4-9b77-3a3ea4d4d330
DOI: 10.1101/416339

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