Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The somatic mutation landscape of the human body.

Genome biology - 24 Dec 2019

García-Nieto Pablo E, Morrison Ashby J, Fraser Hunter B

Abstract excerpt

BACKGROUND: Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized. RESULTS: To gain a better understanding of the genome-wide distribution and functional impact of somatic mutations, we leverage the genomic information contained in the transcriptome to uniformly call somatic mutations from over 7500 tissue samples, representing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aging
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MLH1 gene

Share to Genetic factors in colorectal cancer

Share to Mutation

Share to Neoplasms

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 31874648
DOI: 10.1186/s13059-019-1919-5
PMCID: PMC6930685

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The somatic mutation landscape of the human body.PMID 31874648Read ↗

The somatic mutation landscape of the human bodySemantic proximity Read ↗

Age-related somatic mutation burden in human tissuesSemantic proximity Read ↗

Landscape of human protein-coding somatic mutations across tissues and individualsSemantic proximity Read ↗

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging.Semantic proximity Read ↗

The impact of rare germline variants on human somatic mutation processesSemantic proximity Read ↗

The impact of rare germline variants on human somatic mutation processes.Semantic proximity Read ↗

SomaMutDB: a database of somatic mutations in normal human tissues.Semantic proximity Read ↗

Somatic mutation in cancer and normal cells.Semantic proximity Read ↗

The origins, determinants, and consequences of human mutations.Semantic proximity Read ↗

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionSemantic proximity Read ↗

Somatic Mutaome Profile in Human Cancer TissuesSemantic proximity Read ↗

Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.