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Article

Landscape of human protein-coding somatic mutations across tissues and individuals

2025-01-09

Abstract excerpt

<h4>Summary</h4> Although somatic mutations are fundamentally important to human biology, disease, and aging, many outstanding questions remain about their rates, spectrum, and determinants in apparently healthy tissues. Here, we performed high-coverage exome sequencing on 265 samples from 14 GTEx donors sampled for a median of 17.5 tissues per donor (spanning 46 total tissues). Using a novel probabilistic method...

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Literature Corpus work
b1d0eb62-2f53-5586-b7c6-c8a4471fa0b1
DOI
10.1101/2025.01.07.631808
Open publication

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Landscape of human protein-coding somatic mutations across tissues and individualsDOI 10.1101/2025.01.07.631808
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