Article

Somatic Variation in Normal Tissues: Friend or Foe of Cancer Early Detection?

2022-07-21

Abstract excerpt

Seemingly normal tissues progressively become populated by mutant clones over time. Most of these clones bear mutations in well-known cancer genes but only rarely do they transform into cancer. This poses questions on what triggers cancer initiation and what implications somatic variation has for cancer early detection. We analysed recent mutational screens of healthy and cancer-free diseased tissues to compare so...

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Literature Corpus work: 3cd63449-0b3f-5598-976c-0845ad05896c
DOI: 10.20944/preprints202207.0321.v1

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