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Article

SomaMutDB: a database of somatic mutations in normal human tissues.

Nucleic acids research - 7 Jan 2022

Sun Shixiang, Wang Yujue, Maslov Alexander Y, Dong Xiao, Vijg Jan

Abstract excerpt

De novo mutations, a consequence of errors in DNA repair or replication, have been reported to accumulate with age in normal tissues of humans and model organisms. This accumulation during development and aging has been implicated as a causal factor in aging and age-related pathology, including but not limited to cancer. Due to their generally very low abundance mutations have been difficult to detect in normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34634815
DOI: 10.1093/nar/gkab914
PMCID: PMC8728264

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