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Article

Somatic variation in normal tissues: friend or foe of cancer early detection?

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2022

Acha-Sagredo A, Ganguli P, Ciccarelli F D

Abstract excerpt

BACKGROUND: Seemingly normal tissues progressively become populated by mutant clones over time. Most of these clones bear mutations in well-known cancer genes but only rarely do they transform into cancer. This poses questions on what triggers cancer initiation and what implications somatic variation has for cancer early detection. DESIGN: We analyzed recent mutational screens of healthy and cancer-free diseased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36162751
DOI: 10.1016/j.annonc.2022.09.156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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