Cells with cancer‐associated mutations overtake our tissues as we age

Abstract excerpt

BACKGROUND: To shed light on the earliest events in oncogenesis, there is growing interest in understanding the mutational landscapes of normal tissues across ages. In the last decade, next-generation sequencing of human tissues has revealed a surprising abundance of cells with what would be considered oncogenic mutations. AIMS: We performed meta-analysis on previously published sequencing data on normal tissues...

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