Article

Transferability of European-derived Alzheimer’s Disease Polygenic Risk Scores across Multi-Ancestry Populations

2023-10-19

Abstract excerpt

A polygenic score (PGS) for Alzheimer’s disease (AD) was recently derived from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with AD risk, age at onset, and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E (APOE) . This PGS was also associated with the AD risk in...

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Literature Corpus work: 895e769b-29e5-5b78-8d50-33abfcb41c67
DOI: 10.1101/2023.10.17.23297061

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