Article

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores is most accurate when using all genetic information.

2021-01-18

Abstract excerpt

<title>Abstract</title> <p>There is little agreement regarding the approach and optimal p-value threshold of SNPs to calculate genetic risk scores for Alzheimer’s disease (AD). This reflects a fundamental underlying debate on the polygenic versus oligogenic disease architecture. We re-investigated the assumptions underlying the choice of specific p-value thresholds defining genetic loci used to determine polygeni...

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Literature Corpus work: 1f92defd-3764-53da-909b-f18d4cbb0e99
DOI: 10.21203/rs.3.rs-137252/v1

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