Common polygenic variation enhances risk prediction for Alzheimer's disease.

doi:10.1093/brain/awv268

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Article

Common polygenic variation enhances risk prediction for Alzheimer's disease.

Brain : a journal of neurology - 1 Dec 2015

Escott-Price Valentina, Sims Rebecca, Bannister Christian, Harold Denise, Vronskaya Maria, Majounie Elisa, Badarinarayan Nandini, Morgan Kevin, Passmore Peter, Holmes Clive, Powell John, Brayne Carol, Gill Michael, Mead Simon, Goate Alison, Cruchaga Carlos, Lambert Jean-Charles, van Duijn Cornelia, Maier Wolfgang, Ramirez Alfredo, Holmans Peter, Jones Lesley, Hardy John, Seshadri Sudha, Schellenberg Gerard D, Amouyel Philippe, Williams Julie

Abstract excerpt

The identification of subjects at high risk for Alzheimer's disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer's disease and the accuracy of Alzheimer's disease prediction models, including and excluding the polygenic component in the model. This study used genotype data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained...

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PMID: 26490334
DOI: 10.1093/brain/awv268
PMCID: PMC5006219

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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