Article
Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes.
JAMA network open - 1 Dec 2022
Jung Sang-Hyuk, Kim Hang-Rai, Chun Min Young, Jang Hyemin, Cho Minyoung, Kim Beomsu, Kim Soyeon, Jeong Jee Hyang, Yoon Soo Jin, Park Kyung Won, Kim Eun-Joo, Yoon Bora, Jang Jae-Won, Kim Yeshin, Hong Jin Yong, Choi Seong Hye, Noh Young, Kim Ko Woon, Kim Si Eun, Lee Jin San, Jung Na-Yeon, Lee Juyoun, Lee Ae Young, Kim Byeong C, Cho Soo Hyun, Cho Hanna, Kim Jong Hun, Jung Young Hee, Lee Dong Young, Lee Jae-Hong, Lee Eek-Sung, Kim Seung Joo, Moon So Young, Son Sang Joon, Hong Chang Hyung, Bae Jin-Sik, Lee Sunghoon, Na Duk L, Seo Sang Won, Cruchaga Carlos, Kim Hee Jin, Won Hong-Hee
Abstract excerpt
Importance: Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease (AD). However, genetic studies have predominantly focused on populations of European ancestry. Objective: To evaluate the transferability of a PRS for AD in the Korean...
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