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Article

Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2026

Olayinka Oluwatosin, Farrell John J, Zhu Congcong, Khurshid Zainab, Martin Eden R, Bush William S, Pericak-Vance Margaret A, Wang Li-San, Schellenberg Gerard D, Haines Jonathan L, Lunetta Kathryn L, Zhang Xiaoling, Farrer Lindsay A

Abstract excerpt

INTRODUCTION: We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs). METHODS: PRSs for European ancestry (EA) participants of the Alzheimer's Disease Sequencing Project were calculated using summary statistics from a large genome-wide association study. Participants were classified into high (n = 5738) and low (n = 5324) PRS groups based on the...

Topics

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Alzheimer Disease
Genetic Predisposition to Disease
Genetic Risk Score
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Multifactorial Inheritance

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42557982
DOI: 10.1002/alz.71710
PMCID: PMC13444717

Genes

ALDH9A1
BICC1
PAN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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