Article

A novel subset of hepatocytes is simultaneously gluconeogenic and <i>de novo</i> lipogenic in the fed state and is naturally insulin resistant

2026-03-11

Abstract excerpt

<h4>ABSTRACT</h4> It is generally accepted that hepatic gluconeogenesis, the synthesis of glucose from non-carbohydrate substrates is active in the fasted state and inactive in the fed state. In contrast, de novo lipogenesis is active in the fed state and is inactive in the fasted state. Here, we used targeted single cell RNA-seq, HCR RNA-FISH, and PrimeFlow in normal physiological mouse liver, and identified a...

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Identifiers and source

Literature Corpus work: 895c91d5-bde1-55a6-bbf8-5dad76afe4a6
DOI: 10.64898/2026.03.09.710526

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A novel subset of hepatocytes is simultaneously gluconeogenic and <i>de novo</i> lipogenic in the fed state and is naturally insulin resistantDOI 10.64898/2026.03.09.710526Read

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