Article

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

2023-12-01

Abstract excerpt

Under chronic stress, cells must balance competing demands between cellular survival and tissue function. In metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD/NASH), hepatocytes cooperate with structural and immune cells to perform crucial metabolic, synthetic, and detoxification functions despite nutrient imbalances. While prior work has emphasized stress-induced drivers of cell deat...

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Literature Corpus work: 9bd855ff-73e4-5bbc-b87a-5b5bf2645ba4
DOI: 10.1101/2023.11.30.569407

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