Article

Lineage recording reveals hijacked hepatic progenitor states as a common origin of HCC and ICC

2026-07-14

Abstract excerpt

<h4>Highlights</h4> CERAMIC enables continuous and high-capacity lineage tracing of liver tumor initiation Fatty liver-associated hepatocytes acquire regenerative and premalignant cell states before malignant transformation Lineage reconstruction identifies Hep_Bi-zonal cells as the cellular origin of liver tumor initiation Transcriptional and regulatory programs distinguish tumor-fated hepatocytes from failed-to...

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Literature Corpus work: 68ccf4c9-f1da-55f6-950c-461cdfe9bed6
DOI: 10.64898/2026.07.13.738237

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