Article

Hepatic aldose reductase drives a Warburg effect-like metabolic reprogramming to promote insulin resistance, fatty liver and obesity

2024-09-23

Abstract excerpt

<h4>Background & Aims</h4> Emerging evidence suggest that abnormal activation of aldose reductase/the polyol pathway (Ar/PP) is associated with the pathogenesis or development of fatty liver, obesity and metabolic syndrome. However, the underlying mechanisms were unclear. In this study, we investigated the metabolic reprogramming following activation or inhibition of Ar, the first and the rate-limiting enzyme of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2093cac2-06b8-5216-a0ec-b5c5a2a1ad75
DOI: 10.1101/2024.09.23.614395

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hepatic aldose reductase drives a Warburg effect-like metabolic reprogramming to promote insulin resistance, fatty liver and obesityDOI 10.1101/2024.09.23.614395Read

Metabolic reprogramming and its clinical implication for liver cancerSemantic proximity Read

Global molecular landscape of early MASLD progression in obesitySemantic proximity Read

Systematic Analysis of Human Tissue- and Cell-Specific Metabolic Models Identifies High-Sugar, High-Fat Diet–Induced Liver DysregulationSemantic proximity Read

Chronic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liverSemantic proximity Read

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.Semantic proximity Read

Targeting the Metabolic Paradigms in Cancer and DiabetesSemantic proximity Read

Metabolic Reprogramming is a Hallmark of Metabolism ItselfSemantic proximity Read

A novel subset of hepatocytes is simultaneously gluconeogenic and <i>de novo</i> lipogenic in the fed state and is naturally insulin resistantSemantic proximity Read

Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axisSemantic proximity Read

Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Deficiency Exacerbates Alcohol-Induced Hepatic Oxidative Stress, Inflammation, Steatosis, and FibrosisSemantic proximity Read

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistanceSemantic proximity Read

A multiomics comparison of weight loss interventions shows the distinct effects of bariatric surgery and intermittent fasting on hepatic metabolismSemantic proximity Read