Article

A Microphysiological Model of Progressive Human Hepatic Insulin Resistance

2025-01-08

Abstract excerpt

<h4>Background & Aims</h4> Hepatic insulin resistance is a fundamental phenomenon observed in both Type 2 diabetes (T2D) and metabolic (dysfunction) associated fatty liver disease (MAFLD). The relative contributions of nutrients, hyperinsulinemia, hormones, inflammation, and other cues are difficult to parse in vivo as they are convoluted by interplay between the local and systemic events. Here, we used a well-e...

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Literature Corpus work: c599483b-323c-5ee1-80d1-ea3c1a3e79c6
DOI: 10.1101/2025.01.08.631261

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