Article

Depletion of Abundant Sequences by Hybridization (DASH): Using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications

2015-11-14

Abstract excerpt

<h4>Background: </h4> With widespread adoption of next-generation sequencing (NGS) technologies, the need has arisen for a broadly applicable method to remove unwanted high-abundance species prior to sequencing. We introduce DASH (Depletion of Abundant Sequences by Hybridization), a facile technique for targeted depletion of undesired sequences. <h4>Results:</h4> Sequencing libraries are DASHed with recombinant Ca...

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Literature Corpus work: 89412bc8-b632-5b70-935d-ec03219bdb0f
DOI: 10.1101/031708

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