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Article

Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE.

Nature biotechnology - 1 Sept 2025

Song Jayeon, Cho Mi Hyeon, Cho Hayoung, Song Younseong, Lee Sung Woon, Nam Ho Chul, Yoon Tae Ho, Shin Jong Cheol, Hong Jae-Sang, Kim Yejin, Ekanayake Emil, Jeon Jueun, You Dong Gil, Im Sung Gap, Choi Gyu-Seog, Park Jun Seok, Carter Bob C, Balaj Leonora, Seo An Na, Miller Miles A, Park Soo Yeun, Kang Taejoon, Castro Cesar M, Lee Hakho

Abstract excerpt

Sequencing of messenger RNA (mRNA) found in extracellular vesicles (EVs) in liquid biopsies can provide clinical information such as somatic mutations, resistance profiles and tumor recurrence. Despite this, EV mRNA remains underused due to its low abundance in liquid biopsies, and large sample volumes or specialized techniques for analysis are required. Here we introduce Self-amplified and CRISPR-aided Operation...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39375445
DOI: 10.1038/s41587-024-02426-6
PMCID: PMC12747296

Genes

BRAF
EGFR
IDH1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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