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Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids

1 Sept 2022

Abstract excerpt

Cell-free DNA (cfDNA) has become the predominant analyte of liquid biopsy; however, recent studies suggest the presence of subnucleosomal-sized DNA fragments in circulation that are likely single-stranded. Here, we report a method called direct capture and sequencing (DCS) tailored to recover such fragments from biofluids by directly capturing them using short degenerate probes followed by single strand-based...

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PMID: 36147958
DOI: 10.1016/j.isci.2022.105046

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