Article
Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics.
Nucleic acids research - 28 Feb 2020
Song Jinzhao, Hegge Jorrit W, Mauk Michael G, Chen Junman, Till Jacob E, Bhagwat Neha, Azink Lotte T, Peng Jing, Sen Moen, Mays Jazmine, Carpenter Erica L, van der Oost John, Bau Haim H
Abstract excerpt
Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence homology with abundant wild-type nucleic acids. We describe a novel approach, dubbed NAVIGATER, for increasing the fractions of Nucleic Acids of clinical interest Via DNA-Guided...
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