FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

Abstract excerpt

<h4>ABSTRACT</h4> The growing prevalence of deadly microbes with resistance to previously life-saving drug therapies is a dire threat to human health. Detection of low abundance pathogen sequences remains a challenge for metagenomic Next Generation Sequencing (NGS). We introduce FLASH (Finding Low Abundance Sequences by Hybridization), a next-generation CRISPR/Cas9 diagnostic method that takes advantage of the ef...

Topics

Open a Topic to create a Post that cites this publication.

• Communicable Diseases
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Genetic Diseases, Inborn
• Nucleic Acid Amplification Techniques
• Point-of-Care Systems
• Polymorphism, Single Nucleotide
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

1b16be7c-b880-5546-aaaf-18bef147d2e4

DOI

10.1101/426338