Article

Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to Interferon Types I, II, and III

2021-12-13

Abstract excerpt

The three types of interferon (IFN) have roles in antimicrobial immunity and inflammation that must be properly balanced to maintain tissue homeostasis. For example, IFNs are elevated in the context of inflammatory bowel disease and may synergize with inflammatory cytokines such as tumor necrosis factor alpha (TNFα) to promote tissue damage. Prior studies suggest that in mouse intestinal epithelial cells (IECs), t...

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Literature Corpus work: 893ec8bd-4dd1-5077-ab24-8566f7456f45
DOI: 10.1101/2021.12.11.472223

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