Article

JAK and TYK2 inhibitors differentially modulate interferon/TNF-driven inflammation, stemness and proliferation in the colonic epithelium of ulcerative colitis

2026-07-20

Abstract excerpt

<h4>Background</h4> Janus kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway is a key regulator of inflammatory signaling in ulcerative colitis (UC). While most studies have focused on JAK/tyrosine kinase 2 (TYK2) inhibitors effects on immune cell-mediated responses, their direct epithelial impact remains less known. We investigated epithelial-specific transcriptional responses to JAK/TY...

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Literature Corpus work: 7678f9df-f0d0-56ed-9174-7021b77c5050
DOI: 10.64898/2026.07.20.739113

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