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Article

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut

1 Apr 2021

Abstract excerpt

Exacerbated pro-inflammatory immune response contributes to COVID-19 pathology. However, despite the mounting evidence about SARS-CoV-2 infecting the human gut, little is known about the antiviral programs triggered in this organ. To address this gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids. We identified a subpopulation of enterocytes as the prime target of SARS-CoV-2...

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PMID: 33904651
DOI: 10.15252/msb.202110232

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