Article

IFN-γ-Induced Intestinal Epithelial Cell-Type-Specific Programmed Cell Death: PANoptosis and Its Modulation in Crohn’s Disease

2025-01-24

Abstract excerpt

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) and is considered a Th1-mediated disease, supported by the over-expression of interferon-gamma (IFN-γ) in the intestinal lamina propria. To evaluate the response of intestinal epithelial cells (IECs) to IFN-γ, we established small intestinal organoids (enteroids) derived from non-IBD controls and CD patients. IFN-γ stimulated programmed cell death...

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Literature Corpus work: 613b1dbc-918c-5c71-900d-0c6646b4cfae
DOI: 10.1101/2025.01.24.634679

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