Article

Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epithelium

2026-01-12

Abstract excerpt

Excessive cell death in the epithelium due to prolonged immune activation is associated with intestinal diseases such as Crohn’s disease. Mice with mutations in the Crohn’s disease susceptibility gene Atg16l1 are susceptible to inflammation associated with intestinal epithelial cell (IEC) death, including loss of antimicrobial Paneth cells triggered by infection with murine norovirus (MNV). Here, we show that int...

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Literature Corpus work: 8a23940b-ebdc-5b81-ac91-f1c403f8e172
DOI: 10.64898/2026.01.10.698817

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