Definition and discovery of tandem SH3-binding motifs interacting with members of the p47 ^phox -related protein family

Abstract excerpt

SH3 domains are widespread protein modules that mostly bind to proline-rich short linear motifs (SLiMs). Most known SH3 domain-motif interactions and canonical or non-canonical recognition specificities are described for individual SH3 domains. Although cooperation and coordinated motif binding between tandem SH3 domains has already been described for members of the p47 phox -related protein family, individual ca...

Topics

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• Amino Acid Motifs
• Cell Line
• Chemical Synthesis and Analysis
• Mutation
• Peptidase Inhibition and Analysis
• Protein Interaction Domains and Motifs
• Protein Kinase Regulation and GTPase Signaling
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

89166a11-a646-53f6-895d-cd7a6eb448fd

DOI

10.1101/2025.09.15.676255